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Interneurons are the main inhibitory class of cells in the brain of mammals. They come in many flavors -- varying in shape, localization, connectivity and intrinsic properties. For decades, interneurons were assumed to simply sum their inputs and, if strong enough, cause the cell to fire. Recent experimental findings however, report nonlinear dendritic events in other interneuron subtypes, implying that interneurons may be much more than simple point devices. Alexandra Tzilivaki et al. This toolset consisted of a full-blown morphologically and biophysically detailed models of Fast Spiking Basket Cells FSBCsb reductions of these cells in the form of artificial neural networks and c a network model, able to form new associative memories.

Young berlin models alexandra

This youg shows the wider implications of considering dendritic nonlinearities in interneurons, a deed that has been ignored for years. Interneurons are the main inhibitory class of cells in the brain of mammals. It also provides a more accurate reductionist description of interneuron processing.

This toolset consisted of a full-blown morphologically and biophysically detailed models of Fast Spiking Basket Cells FSBCsb reductions of these cells in the form of artificial neural networks and c a network model, able to form new associative memories. Alexandra Tzilivaki et al. Taking it one-step further, the network model simulation outcomes showed that the nonlinear dendrites of FSBCs can ificantly enhance learning and memory, compared to a respective network with only point FSBCs implemented with linear dendrites.

Young berlin models alexandra

Depending on their morphology and biophysics, these dendrites could either boost incoming inputs supra-linear dendrites or suppress them sub-linear dendrites. In summary, this work provides a novel view of dendritic integration in FS interneurons that extends in hippocampal and cortical areas. The first interesting finding was that in all the model cells tested, in both brain areas, FSBCs had non-linear dendrites.

Young berlin models alexandra

Nature Communications. This finding raises this particular interneuron subtype to the same level of processing power as pyramidal neurons, the main excitatory neurons involved in most akexandra behaviors, including learning and memory.

Young berlin models alexandra

The presence of these nonlinearities enabled individual FSBCs to produce a wide range of responses that could alexandraa be captured by a point neuron reduction. Further experimental testing will broaden our understanding of how interneurons exploit their complex dendritic processing capabilities so as to contribute to complex brain functions. Publication: Tzilivaki A.

They come in many flavors -- varying in shape, localization, connectivity and intrinsic properties. With hands.

Verlin experimental findings however, report nonlinear dendritic events in other interneuron mocels, implying that interneurons may be much more than simple point devices. Instead, the best way to capture what an FSBC is actually computing is to assume a 2-layer Artificial Neural Network that incorporates the two types of dendrites, found in these cells: supra-linear and sub-linear.

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For decades, interneurons were assumed to simply sum their inputs and, if strong enough, cause the cell to fire. Your IP made too many requests to our servers and we need to check that you are modela real human being.

Young berlin models alexandra

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